Assessment of simple movements reflects impairment in Huntington's disease
Identifieur interne : 003585 ( Main/Exploration ); précédent : 003584; suivant : 003586Assessment of simple movements reflects impairment in Huntington's disease
Auteurs : Carsten Saft [Allemagne] ; Jürgen Andrich [Allemagne] ; Nina-Marie Meisel [Allemagne] ; Horst Przuntek [Allemagne] ; Thomas Müller [Allemagne]Source :
- Movement Disorders [ 0885-3185 ] ; 2006-08.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
- Adult, Female, Heterozygote Detection, Humans, Huntington Disease (genetics), Huntington Disease (physiopathology), Huntington Disease (psychology), Huntington disease, Huntington's disease, Male, Middle Aged, Movement (physiology), Movement Disorders (etiology), Movement Disorders (physiopathology), Nervous system diseases, Neuropsychological Tests, Tapping, Trinucleotide Repeat Expansion, fine motor skills, tapping.
- MESH :
- etiology : Movement Disorders.
- genetics : Huntington Disease.
- physiology : Movement.
- physiopathology : Huntington Disease, Movement Disorders.
- psychology : Huntington Disease.
- Adult, Female, Heterozygote Detection, Humans, Male, Middle Aged, Neuropsychological Tests, Trinucleotide Repeat Expansion.
Abstract
Clinical rating, caudate atrophy, disturbed movement performance, neuropsychological testing, and age‐related genetic disease load (CAG index) are tools that reflect impairment after onset of Huntington's disease (HD). Objectives were to compare scored HD symptoms, results of neuropsychological testing and of instrumental measurement of simple motion sequences, assess caudate atrophy and CAG index, and investigate their relation to each other in 131 subjects of various HD stages. Caudate atrophy and CAG index significantly increased in advanced HD patients. Motor test results significantly differed between HD patients and 49 controls, but not between HD gene carriers and controls. Instrumental test outcomes, scored HD intensity, caudate atrophy, and CAG index significantly correlated to each other. Neuropsychological testing, which we only performed in the HD gene carriers and the previously untreated HD patients, reflected the early appearance of HD symptoms and correlated with the motor test results. Results of our applied instrumental tool measure impaired movement performance, which is not specific for HD, but reflects the various methods assessed and the slowly evolving symptoms of the degenerative process in HD. © 2006 Movement Disorder Society
Url:
DOI: 10.1002/mds.20939
Affiliations:
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Le document en format XML
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Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2006-08">2006-08</date><biblScope unit="vol">21</biblScope><biblScope unit="issue">8</biblScope><biblScope unit="page" from="1208">1208</biblScope><biblScope unit="page" to="1212">1212</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">EE5EE941857095FF7E2A8C26706457A57D290CA5</idno><idno type="DOI">10.1002/mds.20939</idno><idno type="ArticleID">MDS20939</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Female</term><term>Heterozygote Detection</term><term>Humans</term><term>Huntington Disease (genetics)</term><term>Huntington Disease (physiopathology)</term><term>Huntington Disease (psychology)</term><term>Huntington disease</term><term>Huntington's disease</term><term>Male</term><term>Middle Aged</term><term>Movement (physiology)</term><term>Movement Disorders (etiology)</term><term>Movement Disorders (physiopathology)</term><term>Nervous system diseases</term><term>Neuropsychological Tests</term><term>Tapping</term><term>Trinucleotide Repeat Expansion</term><term>fine motor skills</term><term>tapping</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Movement Disorders</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Huntington Disease</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Movement</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Huntington Disease</term><term>Movement Disorders</term></keywords><keywords scheme="MESH" qualifier="psychology" xml:lang="en"><term>Huntington Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Female</term><term>Heterozygote Detection</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Neuropsychological Tests</term><term>Trinucleotide Repeat Expansion</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Chorée Huntington</term><term>Système nerveux pathologie</term><term>Taraudage</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Clinical rating, caudate atrophy, disturbed movement performance, neuropsychological testing, and age‐related genetic disease load (CAG index) are tools that reflect impairment after onset of Huntington's disease (HD). Objectives were to compare scored HD symptoms, results of neuropsychological testing and of instrumental measurement of simple motion sequences, assess caudate atrophy and CAG index, and investigate their relation to each other in 131 subjects of various HD stages. Caudate atrophy and CAG index significantly increased in advanced HD patients. Motor test results significantly differed between HD patients and 49 controls, but not between HD gene carriers and controls. Instrumental test outcomes, scored HD intensity, caudate atrophy, and CAG index significantly correlated to each other. Neuropsychological testing, which we only performed in the HD gene carriers and the previously untreated HD patients, reflected the early appearance of HD symptoms and correlated with the motor test results. Results of our applied instrumental tool measure impaired movement performance, which is not specific for HD, but reflects the various methods assessed and the slowly evolving symptoms of the degenerative process in HD. © 2006 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>Allemagne</li></country></list><tree><country name="Allemagne"><noRegion><name sortKey="Saft, Carsten" sort="Saft, Carsten" uniqKey="Saft C" first="Carsten" last="Saft">Carsten Saft</name></noRegion><name sortKey="Andrich, Jurgen" sort="Andrich, Jurgen" uniqKey="Andrich J" first="Jürgen" last="Andrich">Jürgen Andrich</name><name sortKey="Meisel, Nina Arie" sort="Meisel, Nina Arie" uniqKey="Meisel N" first="Nina-Marie" last="Meisel">Nina-Marie Meisel</name><name sortKey="Muller, Thomas" sort="Muller, Thomas" uniqKey="Muller T" first="Thomas" last="Müller">Thomas Müller</name><name sortKey="Przuntek, Horst" sort="Przuntek, Horst" uniqKey="Przuntek H" first="Horst" last="Przuntek">Horst Przuntek</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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